Probability models for DNA sequence evolution
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چکیده
منابع مشابه
Probability Models for DNA Sequence Evolution
ing from the example, suppose that there are n subpopulations that have reached equilibrium sizes N1, . . . Nn and let mij be the probability that an individual in subpopulation i is a descendant of an individual in subpopulation j. That is, to build up subpopulation i in generation t + 1, we sample Ni times with replacement from generation t, picking at random from subpopulation j with probabi...
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Probabilistic models of sequence evolution are in widespread use in phylogenetics and molecular sequence evolution. These models have become increasingly sophisticated and combined with statistical model comparison techniques have helped to shed light on how genes and proteins evolve. Models of codon evolution have been particularly useful, because, in addition to providing a significant improv...
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A quantitative model is proposed for the expected degree of relationship between copies of a family of transposable elements in a finite population of hosts. Special cases of the model (in which the process of homogenization of element copies either is or is not limited by transposition rate) are presented and illustrated, using data on mobile sequences from different species. It is shown that ...
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Simple repetitive DNA sequences are a widespread and abundant feature of genomic DNA. The following several features characterize such sequences: (1) they typically consist of a variety of repeated motifs of 1-10 bases--but may include much larger repeats as well; (2) larger repeat units often include shorter ones within them; (3) long polypyrimidine and poly-CA tracts are often found; and (4) ...
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In considering the degree of similarity that we expect by chance, these scoring functions allow us to compare two alignments by comparing their scores, but are less useful for assessing a pairwise alignment in an absolute sense. Given a pair of aligned sequences with a particular collection of matches, mismatches, and indels, does the alignment reflect enough similarity to suggest that it is of...
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ژورنال
عنوان ژورنال: Heredity
سال: 2004
ISSN: 0018-067X,1365-2540
DOI: 10.1038/sj.hdy.6800419